Multiple Instance Learning for Glioma Diagnosis using Hematoxylin and Eosin Whole Slide Images: An Indian Cohort Study

The effective management of brain tumors relies on precise typing, subtyping, and grading. This study advances patient care with findings from rigorous multiple instance learning experimentations across various feature extractors and aggregators in brain tumor histopathology. It establishes new performance benchmarks in glioma subtype classification across multiple datasets, including a novel dataset focused on the Indian demographic (IPD- Brain), providing a valuable resource for existing research. Using a ResNet-50, pretrained on histopathology datasets for feature extraction, combined with the Double-Tier Feature Distillation (DTFD) feature aggregator, our approach achieves state-of-the-art AUCs of 88.08 on IPD-Brain and 95.81 on the TCGA-Brain dataset, respectively, for three-way glioma subtype classification. Moreover, it establishes new benchmarks in grading and detecting IHC molecular biomarkers (IDH1R132H, TP53, ATRX, Ki-67) through H&E stained whole slide images for the IPD-Brain dataset. The work also highlights a significant correlation between the model decision-making processes and the diagnostic reasoning of pathologists, underscoring its capability to mimic professional diagnostic procedures.

LRH-Net: A Multi-Level Knowledge Distillation Approach for Low-Resource Heart Network

An electrocardiogram (ECG) monitors the electrical activity generated by the heart and is used to detect fatal cardiovascular diseases (CVDs). Conventionally, to capture the precise electrical activity, clinical experts use multiple-lead ECGs (typically 12 leads). But in recent times, large-size deep learning models have been used to detect these diseases. However, such models require heavy compute resources like huge memory and long inference time. To alleviate these shortcomings, we propose a low-parameter model, named Low Resource Heart-Network (LRH-Net), which uses fewer leads to detect ECG anomalies in a resource-constrained environment. A multi-level knowledge distillation process is used on top of that to get better generalization performance on our proposed model. The multi-level knowledge distillation process distills the knowledge to LRH-Net trained on a reduced number of leads from higher parameter (teacher) models trained on multiple leads to reduce the performance gap. The proposed model is evaluated on the PhysioNet-2020 challenge dataset with constrained input. The parameters of the LRH-Net are 106x less than our teacher model for detecting CVDs. The performance of the LRH-Net was scaled up to 3.2% and the inference time scaled down by 75% compared to the teacher model. In contrast to the compute- and parameter-intensive deep learning techniques, the proposed methodology uses a subset of ECG leads using the low resource LRH-Net, making it eminently suitable for deployment on edge devices.