Machine learning for prediction of dose-volume histograms of organs-at-risk in prostate cancer from simple structure volume parameters

Dose prediction is an area of ongoing research that facilitates radiotherapy planning. Most commercial models utilise imaging data and intense computing resources. This study aimed to predict the dose-volume of rectum and bladder from volumes of target, at-risk structure organs and their overlap regions using machine learning. Dose-volume information of 94 patients with prostate cancer planned for 6000cGy in 20 fractions was exported from the treatment planning system as text files and mined to create a training dataset. Several statistical modelling, machine learning methods, and a new fuzzy rule-based prediction (FRBP) model were explored and validated on an independent dataset of 39 patients. The median absolute error was 2.0%-3.7% for bladder and 1.7-2.4% for rectum in the 4000-6420cGy range. For 5300cGy, 5600cGy and 6000cGy, the median difference was less than 2.5% for rectum and 3.8% for bladder. The FRBP model produced errors of 1.2%, 1.3%, 0.9% and 1.6%, 1.2%, 0.1% for the rectum and bladder respectively at these dose levels. These findings indicate feasibility of obtaining accurate predictions of the clinically important dose-volume parameters for rectum and bladder using just the volumes of these structures.

Inter Observer Variability Assessment through Ordered Weighted Belief Divergence Measure in MAGDM Application to the Ensemble Classifier Feature Fusion

A large number of multi-attribute group decisionmaking (MAGDM) have been widely introduced to obtain consensus results. However, most of the methodologies ignore the conflict among the experts opinions and only consider equal or variable priorities of them. Therefore, this study aims to propose an Evidential MAGDM method by assessing the inter-observational variability and handling uncertainty that emerges between the experts. The proposed framework has fourfold contributions. First, the basic probability assignment (BPA) generation method is introduced to consider the inherent characteristics of each alternative by computing the degree of belief. Second, the ordered weighted belief and plausibility measure is constructed to capture the overall intrinsic information of the alternative by assessing the inter-observational variability and addressing the conflicts emerging between the group of experts. An ordered weighted belief divergence measure is constructed to acquire the weighted support for each group of experts to obtain the final preference relationship. Finally, we have shown an illustrative example of the proposed Evidential MAGDM framework. Further, we have analyzed the interpretation of Evidential MAGDM in the real-world application for ensemble classifier feature fusion to diagnose retinal disorders using optical coherence tomography images.

Multiscale Color Guided Attention Ensemble Classifier for Age-Related Macular Degeneration using Concurrent Fundus and Optical Coherence Tomography Images

Automatic diagnosis techniques have evolved to identify age-related macular degeneration (AMD) by employing single modality Fundus images or optical coherence tomography (OCT). To classify ocular diseases, fundus and OCT images are the most crucial imaging modalities used in the clinical setting. Most deep learning-based techniques are established on a single imaging modality, which contemplates the ocular disorders to a specific extent and disregards other modality that comprises exhaustive information among distinct imaging modalities. This paper proposes a modality-specific multiscale color space embedding integrated with the attention mechanism based on transfer learning for classification (MCGAEc), which can efficiently extract the distinct modality information at various scales using the distinct color spaces. In this work, we first introduce the modality-specific multiscale color space encoder model, which includes diverse feature representations by integrating distinct characteristic color spaces on a multiscale into a unified framework. The extracted features from the prior encoder module are incorporated with the attention mechanism to extract the global features representation, which is integrated with the prior extracted features and transferred to the random forest classifier for the classification of AMD. To analyze the performance of the proposed MCGAEc method, a publicly available multi-modality dataset from Project Macula for AMD is utilized and compared with the existing models.

Speckle Noise Reduction in Ultrasound Images using Denoising Auto-encoder with Skip Connection

Ultrasound is a widely used medical tool for non-invasive diagnosis, but its images often contain speckle noise which can lower their resolution and contrast-to-noise ratio. This can make it more difficult to extract, recognize, and analyze features in the images, as well as impair the accuracy of computer-assisted diagnostic techniques and the ability of doctors to interpret the images. Reducing speckle noise, therefore, is a crucial step in the preprocessing of ultrasound images. Researchers have proposed several speckle reduction methods, but no single method takes all relevant factors into account. In this paper, we compare seven such methods: Median, Gaussian, Bilateral, Average, Weiner, Anisotropic and Denoising auto-encoder without and with skip connections in terms of their ability to preserve features and edges while effectively reducing noise. In an experimental study, a convolutional noise-removing auto-encoder with skip connection, a deep learning method, was used to improve ultrasound images of breast cancer. This method involved adding speckle noise at various levels. The results of the deep learning method were compared to those of traditional image enhancement methods, and it was found that the proposed method was more effective. To assess the performance of these algorithms, we use three established evaluation metrics and present both filtered images and statistical data.