Inverting Neural Networks: New Methods to Generate Neural Network Inputs from Prescribed Outputs

Neural network systems describe complex mappings that can be very difficult to understand. In this paper, we study the inverse problem of determining the input images that get mapped to specific neural network classes. Ultimately, we expect that these images contain recognizable features that are associated with their corresponding class classifications. We introduce two general methods for solving the inverse problem. In our forward pass method, we develop an inverse method based on a root-finding algorithm and the Jacobian with respect to the input image. In our backward pass method, we iteratively invert each layer, at the top. During the inversion process, we add random vectors sampled from the null-space of each linear layer. We demonstrate our new methods on both transformer architectures and sequential networks based on linear layers. Unlike previous methods, we show that our new methods are able to produce random-like input images that yield near perfect classification scores in all cases, revealing vulnerabilities in the underlying networks. Hence, we conclude that the proposed methods provide a more comprehensive coverage of the input image spaces that solve the inverse mapping problem.

Explainable AI applications in the Medical Domain: a systematic review

Artificial Intelligence in Medicine has made significant progress with emerging applications in medical imaging, patient care, and other areas. While these applications have proven successful in retrospective studies, very few of them were applied in practice.The field of Medical AI faces various challenges, in terms of building user trust, complying with regulations, using data ethically.Explainable AI (XAI) aims to enable humans understand AI and trust its results. This paper presents a literature review on the recent developments of XAI solutions for medical decision support, based on a representative sample of 198 articles published in recent years. The systematic synthesis of the relevant articles resulted in several findings. (1) model-agnostic XAI techniques were mostly employed in these solutions, (2) deep learning models are utilized more than other types of machine learning models, (3) explainability was applied to promote trust, but very few works reported the physicians participation in the loop, (4) visual and interactive user interface is more useful in understanding the explanation and the recommendation of the system. More research is needed in collaboration between medical and AI experts, that could guide the development of suitable frameworks for the design, implementation, and evaluation of XAI solutions in medicine.

What do we need to build explainable AI systems for the medical domain?

Artificial intelligence (AI) generally and machine learning (ML) specifically demonstrate impressive practical success in many different application domains, e.g. in autonomous driving, speech recognition, or recommender systems. Deep learning approaches, trained on extremely large data sets or using reinforcement learning methods have even exceeded human performance in visual tasks, particularly on playing games such as Atari, or mastering the game of Go. Even in the medical domain there are remarkable results. The central problem of such models is that they are regarded as black-box models and even if we understand the underlying mathematical principles, they lack an explicit declarative knowledge representation, hence have difficulty in generating the underlying explanatory structures. This calls for systems enabling to make decisions transparent, understandable and explainable. A huge motivation for our approach are rising legal and privacy aspects. The new European General Data Protection Regulation entering into force on May 25th 2018, will make black-box approaches difficult to use in business. This does not imply a ban on automatic learning approaches or an obligation to explain everything all the time, however, there must be a possibility to make the results re-traceable on demand. In this paper we outline some of our research topics in the context of the relatively new area of explainable-AI with a focus on the application in medicine, which is a very special domain. This is due to the fact that medical professionals are working mostly with distributed heterogeneous and complex sources of data. In this paper we concentrate on three sources: images, *omics data and text. We argue that research in explainable-AI would generally help to facilitate the implementation of AI/ML in the medical domain, and specifically help to facilitate transparency and trust.