Leveraging Transfer Learning and Multiple Instance Learning for HER2 Automatic Scoring of H\&E Whole Slide Images

Expression of human epidermal growth factor receptor 2 (HER2) is an important biomarker in breast cancer patients who can benefit from cost-effective automatic Hematoxylin and Eosin (H\&E) HER2 scoring. However, developing such scoring models requires large pixel-level annotated datasets. Transfer learning allows prior knowledge from different datasets to be reused while multiple-instance learning (MIL) allows the lack of detailed annotations to be mitigated. The aim of this work is to examine the potential of transfer learning on the performance of deep learning models pre-trained on (i) Immunohistochemistry (IHC) images, (ii) H\&E images and (iii) non-medical images. A MIL framework with an attention mechanism is developed using pre-trained models as patch-embedding models. It was found that embedding models pre-trained on H\&E images consistently outperformed the others, resulting in an average AUC-ROC value of $0.622$ across the 4 HER2 scores ($0.59-0.80$ per HER2 score). Furthermore, it was found that using multiple-instance learning with an attention layer not only allows for good classification results to be achieved, but it can also help with producing visual indication of HER2-positive areas in the H\&E slide image by utilising the patch-wise attention weights.

Weakly Supervised Co-training with Swapping Assignments for Semantic Segmentation

Class activation maps (CAMs) are commonly employed in weakly supervised semantic segmentation (WSSS) to produce pseudo-labels. Due to incomplete or excessive class activation, existing studies often resort to offline CAM refinement, introducing additional stages or proposing offline modules. This can cause optimization difficulties for single-stage methods and limit generalizability. In this study, we aim to reduce the observed CAM inconsistency and error to mitigate reliance on refinement processes. We propose an end-to-end WSSS model incorporating guided CAMs, wherein our segmentation model is trained while concurrently optimizing CAMs online. Our method, Co-training with Swapping Assignments (CoSA), leverages a dual-stream framework, where one sub-network learns from the swapped assignments generated by the other. We introduce three techniques: i) soft perplexity-based regularization to penalize uncertain regions; ii) a threshold-searching approach to dynamically revise the confidence threshold; and iii) contrastive separation to address the coexistence problem. CoSA demonstrates exceptional performance, achieving mIoU of 76.2\% and 51.0\% on VOC and COCO validation datasets, respectively, surpassing existing baselines by a substantial margin. Notably, CoSA is the first single-stage approach to outperform all existing multi-stage methods including those with additional supervision. Code is avilable at \url{https://github.com/youshyee/CoSA}.

3D Points Splatting for Real-Time Dynamic Hand Reconstruction

We present 3D Points Splatting Hand Reconstruction (3D-PSHR), a real-time and photo-realistic hand reconstruction approach. We propose a self-adaptive canonical points upsampling strategy to achieve high-resolution hand geometry representation. This is followed by a self-adaptive deformation that deforms the hand from the canonical space to the target pose, adapting to the dynamic changing of canonical points which, in contrast to the common practice of subdividing the MANO model, offers greater flexibility and results in improved geometry fitting. To model texture, we disentangle the appearance color into the intrinsic albedo and pose-aware shading, which are learned through a Context-Attention module. Moreover, our approach allows the geometric and the appearance models to be trained simultaneously in an end-to-end manner. We demonstrate that our method is capable of producing animatable, photorealistic and relightable hand reconstructions using multiple datasets, including monocular videos captured with handheld smartphones and large-scale multi-view videos featuring various hand poses. We also demonstrate that our approach achieves real-time rendering speeds while simultaneously maintaining superior performance compared to existing state-of-the-art methods.

A Probabilistic Attention Model with Occlusion-aware Texture Regression for 3D Hand Reconstruction from a Single RGB Image

Recently, deep learning based approaches have shown promising results in 3D hand reconstruction from a single RGB image. These approaches can be roughly divided into model-based approaches, which are heavily dependent on the model's parameter space, and model-free approaches, which require large numbers of 3D ground truths to reduce depth ambiguity and struggle in weakly-supervised scenarios. To overcome these issues, we propose a novel probabilistic model to achieve the robustness of model-based approaches and reduced dependence on the model's parameter space of model-free approaches. The proposed probabilistic model incorporates a model-based network as a prior-net to estimate the prior probability distribution of joints and vertices. An Attention-based Mesh Vertices Uncertainty Regression (AMVUR) model is proposed to capture dependencies among vertices and the correlation between joints and mesh vertices to improve their feature representation. We further propose a learning based occlusion-aware Hand Texture Regression model to achieve high-fidelity texture reconstruction. We demonstrate the flexibility of the proposed probabilistic model to be trained in both supervised and weakly-supervised scenarios. The experimental results demonstrate our probabilistic model's state-of-the-art accuracy in 3D hand and texture reconstruction from a single image in both training schemes, including in the presence of severe occlusions.