Low-Rank Adaptation of Time Series Foundational Models for Out-of-Domain Modality Forecasting

Low-Rank Adaptation (LoRA) is a widely used technique for fine-tuning large pre-trained or foundational models across different modalities and tasks. However, its application to time series data, particularly within foundational models, remains underexplored. This paper examines the impact of LoRA on contemporary time series foundational models: Lag-Llama, MOIRAI, and Chronos. We demonstrate LoRA's fine-tuning potential for forecasting the vital signs of sepsis patients in intensive care units (ICUs), emphasizing the models' adaptability to previously unseen, out-of-domain modalities. Integrating LoRA aims to enhance forecasting performance while reducing inefficiencies associated with fine-tuning large models on limited domain-specific data. Our experiments show that LoRA fine-tuning of time series foundational models significantly improves forecasting, achieving results comparable to state-of-the-art models trained from scratch on similar modalities. We conduct comprehensive ablation studies to demonstrate the trade-offs between the number of tunable parameters and forecasting performance and assess the impact of varying LoRA matrix ranks on model performance.

Interpretable Vital Sign Forecasting with Model Agnostic Attention Maps

Sepsis is a leading cause of mortality in intensive care units (ICUs), representing a substantial medical challenge. The complexity of analyzing diverse vital signs to predict sepsis further aggravates this issue. While deep learning techniques have been advanced for early sepsis prediction, their 'black-box' nature obscures the internal logic, impairing interpretability in critical settings like ICUs. This paper introduces a framework that combines a deep learning model with an attention mechanism that highlights the critical time steps in the forecasting process, thus improving model interpretability and supporting clinical decision-making. We show that the attention mechanism could be adapted to various black box time series forecasting models such as N-HiTS and N-BEATS. Our method preserves the accuracy of conventional deep learning models while enhancing interpretability through attention-weight-generated heatmaps. We evaluated our model on the eICU-CRD dataset, focusing on forecasting vital signs for sepsis patients. We assessed its performance using mean squared error (MSE) and dynamic time warping (DTW) metrics. We explored the attention maps of N-HiTS and N-BEATS, examining the differences in their performance and identifying crucial factors influencing vital sign forecasting.

Vital Sign Forecasting for Sepsis Patients in ICUs

Sepsis and septic shock are a critical medical condition affecting millions globally, with a substantial mortality rate. This paper uses state-of-the-art deep learning (DL) architectures to introduce a multi-step forecasting system to predict vital signs indicative of septic shock progression in Intensive Care Units (ICUs). Our approach utilizes a short window of historical vital sign data to forecast future physiological conditions. We introduce a DL-based vital sign forecasting system that predicts up to 3 hours of future vital signs from 6 hours of past data. We further adopt the DILATE loss function to capture better the shape and temporal dynamics of vital signs, which are critical for clinical decision-making. We compare three DL models, N-BEATS, N-HiTS, and Temporal Fusion Transformer (TFT), using the publicly available eICU Collaborative Research Database (eICU-CRD), highlighting their forecasting capabilities in a critical care setting. We evaluate the performance of our models using mean squared error (MSE) and dynamic time warping (DTW) metrics. Our findings show that while TFT excels in capturing overall trends, N-HiTS is superior in retaining short-term fluctuations within a predefined range. This paper demonstrates the potential of deep learning in transforming the monitoring systems in ICUs, potentially leading to significant improvements in patient care and outcomes by accurately forecasting vital signs to assist healthcare providers in detecting early signs of physiological instability and anticipating septic shock.