Content-Aware Preserving Image Generation

Remarkable progress has been achieved in image generation with the introduction of generative models. However, precisely controlling the content in generated images remains a challenging task due to their fundamental training objective. This paper addresses this challenge by proposing a novel image generation framework explicitly designed to incorporate desired content in output images. The framework utilizes advanced encoding techniques, integrating subnetworks called content fusion and frequency encoding modules. The frequency encoding module first captures features and structures of reference images by exclusively focusing on selected frequency components. Subsequently, the content fusion module generates a content-guiding vector that encapsulates desired content features. During the image generation process, content-guiding vectors from real images are fused with projected noise vectors. This ensures the production of generated images that not only maintain consistent content from guiding images but also exhibit diverse stylistic variations. To validate the effectiveness of the proposed framework in preserving content attributes, extensive experiments are conducted on widely used benchmark datasets, including Flickr-Faces-High Quality, Animal Faces High Quality, and Large-scale Scene Understanding datasets.

Multicell-Fold: geometric learning in folding multicellular life

During developmental processes such as embryogenesis, how a group of cells fold into specific structures, is a central question in biology that defines how living organisms form. Establishing tissue-level morphology critically relies on how every single cell decides to position itself relative to its neighboring cells. Despite its importance, it remains a major challenge to understand and predict the behavior of every cell within the living tissue over time during such intricate processes. To tackle this question, we propose a geometric deep learning model that can predict multicellular folding and embryogenesis, accurately capturing the highly convoluted spatial interactions among cells. We demonstrate that multicellular data can be represented with both granular and foam-like physical pictures through a unified graph data structure, considering both cellular interactions and cell junction networks. We successfully use our model to achieve two important tasks, interpretable 4-D morphological sequence alignment, and predicting local cell rearrangements before they occur at single-cell resolution. Furthermore, using an activation map and ablation studies, we demonstrate that cell geometries and cell junction networks together regulate local cell rearrangement which is critical for embryo morphogenesis. This approach provides a novel paradigm to study morphogenesis, highlighting a unified data structure and harnessing the power of geometric deep learning to accurately model the mechanisms and behaviors of cells during development. It offers a pathway toward creating a unified dynamic morphological atlas for a variety of developmental processes such as embryogenesis.