Safe maneuvering capability is critical for mobile robots in complex environments. However, robotic system dynamics are often time-varying, uncertain, or even unknown during the motion planning and control process. Therefore, many existing model-based reinforcement learning (RL) methods could not achieve satisfactory reliability in guaranteeing safety. To address this challenge, we propose a two-level Vector Field-guided Learning Predictive Control (VF-LPC) approach that guarantees safe maneuverability. The first level, the guiding level, generates safe desired trajectories using the designed kinodynamic guiding vector field, enabling safe motion in obstacle-dense environments. The second level, the Integrated Motion Planning and Control (IMPC) level, first uses the deep Koopman operator to learn a nominal dynamics model offline and then updates the model uncertainties online using sparse Gaussian processes (GPs). The learned dynamics and game-based safe barrier function are then incorporated into the learning predictive control framework to generate near-optimal control sequences. We conducted tests to compare the performance of VF-LPC with existing advanced planning methods in an obstacle-dense environment. The simulation results show that it can generate feasible trajectories quickly. Then, VF-LPC is evaluated against motion planning methods that employ model predictive control (MPC) and RL in high-fidelity CarSim software. The results show that VF-LPC outperforms them under metrics of completion time, route length, and average solution time. We also carried out path-tracking control tests on a racing road to validate the model uncertainties learning capability. Finally, we conducted real-world experiments on a Hongqi E-HS3 vehicle, further validating the VF-LPC approach's effectiveness.