Video-based action recognition has recently attracted much attention in the field of computer vision. To solve more complex recognition tasks, it has become necessary to distinguish different levels of interclass variations. Inspired by a common flowchart based on the human decision-making process that first narrows down the probable classes and then applies a "rethinking" process for finer-level recognition, we propose an effective universal-to-specific (U2S) framework for complex action recognition. The U2S framework is composed of three subnetworks: a universal network, a category-specific network, and a mask network. The universal network first learns universal feature representations. The mask network then generates attention masks for confusing classes through category regularization based on the output of the universal network. The mask is further used to guide the category-specific network for class-specific feature representations. The entire framework is optimized in an end-to-end manner. Experiments on a variety of benchmark datasets, e.g., the Something-Something, UCF101, and HMDB51 datasets, demonstrate the effectiveness of the U2S framework; i.e., U2S can focus on discriminative spatiotemporal regions for confusing categories. We further visualize the relationship between different classes, showing that U2S indeed improves the discriminability of learned features. Moreover, the proposed U2S model is a general framework and may adopt any base recognition network.