Ultra-high resolution multimodal MRI dense labelled holistic brain atlas

In this paper, we introduce holiAtlas, a holistic, multimodal and high-resolution human brain atlas. This atlas covers different levels of details of the human brain anatomy, from the organ to the substructure level, using a new dense labelled protocol generated from the fusion of multiple local protocols at different scales. This atlas has been constructed averaging images and segmentations of 75 healthy subjects from the Human Connectome Project database. Specifically, MR images of T1, T2 and WMn (White Matter nulled) contrasts at 0.125 $mm^{3}$ resolution that were nonlinearly registered and averaged using symmetric group-wise normalisation to construct the atlas. At the finest level, the holiAtlas protocol has 350 different labels derived from 10 different delineation protocols. These labels were grouped at different scales to provide a holistic view of the brain at different levels in a coherent and consistent manner. This multiscale and multimodal atlas can be used for the development of new ultra-high resolution segmentation methods that can potentially leverage the early detection of neurological disorders.