Task offloading is a potential solution to satisfy the strict requirements of computation-intensive and latency-sensitive vehicular applications due to the limited onboard computing resources. However, the overwhelming upload traffic may lead to unacceptable uploading time. To tackle this issue, for tasks taking environmental data as input, the data perceived by roadside units (RSU) equipped with several sensors can be directly exploited for computation, resulting in a novel task offloading paradigm with integrated communications, sensing and computing (I-CSC). With this paradigm, vehicles can select to upload their sensed data to RSUs or transmit computing instructions to RSUs during the offloading. By optimizing the computation mode and network resources, in this paper, we investigate an I-CSC-based task offloading problem to reduce the cost caused by resource consumption while guaranteeing the latency of each task. Although this non-convex problem can be handled by the alternating minimization (AM) algorithm that alternatively minimizes the divided four sub-problems, it leads to high computational complexity and local optimal solution. To tackle this challenge, we propose a creative structural knowledge-driven meta-learning (SKDML) method, involving both the model-based AM algorithm and neural networks. Specifically, borrowing the iterative structure of the AM algorithm, also referred to as structural knowledge, the proposed SKDML adopts long short-term memory (LSTM) network-based meta-learning to learn an adaptive optimizer for updating variables in each sub-problem, instead of the handcrafted counterpart in the AM algorithm.