Multilingual language models (MLMs) acquire valuable, generalizable linguistic information during pretraining and have advanced the state of the art on task-specific finetuning. So far, only ~ 28 out of ~2,000 African languages are covered in existing language models. We ameliorate this limitation by developing SERENGETI, a set of massively multilingual language model that covers 517 African languages and language varieties. We evaluate our novel models on eight natural language understanding tasks across 20 datasets, comparing to four MLMs that each cover any number of African languages. SERENGETI outperforms other models on 11 datasets across the eights tasks and achieves 82.27 average F-1. We also perform error analysis on our models' performance and show the influence of mutual intelligibility when the models are applied under zero-shot settings. We will publicly release our models for research.