The global occurrence, scale, and frequency of wildfires pose significant threats to ecosystem services and human livelihoods. To effectively quantify and attribute the antecedent conditions for wildfires, a thorough understanding of Earth system dynamics is imperative. In response, we introduce the SeasFire datacube, a meticulously curated spatiotemporal dataset tailored for global sub-seasonal to seasonal wildfire modeling via Earth observation. The SeasFire datacube comprises of 59 variables encompassing climate, vegetation, oceanic indices, and human factors, has an 8-day temporal resolution and a spatial resolution of 0.25$^{\circ}$, and spans from 2001 to 2021. We showcase the versatility of SeasFire for exploring the variability and seasonality of wildfire drivers, modeling causal links between ocean-climate teleconnections and wildfires, and predicting sub-seasonal wildfire patterns across multiple timescales with a Deep Learning model. We publicly release the SeasFire datacube and appeal to Earth system scientists and Machine Learning practitioners to use it for an improved understanding and anticipation of wildfires.