Railway Turnout Machines (RTMs) are mission-critical components of the railway transportation infrastructure, responsible for directing trains onto desired tracks. For safety assurance applications, especially in early-warning scenarios, RTM faults are expected to be detected as early as possible on a continuous 7x24 basis. However, limited emphasis has been placed on distributed model inference frameworks that can meet the inference latency and reliability requirements of such mission critical fault diagnosis systems. In this paper, an edge-cloud collaborative early-warning system is proposed to enable real-time and downtime-tolerant fault diagnosis of RTMs, providing a new paradigm for the deployment of models in safety-critical scenarios. Firstly, a modular fault diagnosis model is designed specifically for distributed deployment, which utilizes a hierarchical architecture consisting of the prior knowledge module, subordinate classifiers, and a fusion layer for enhanced accuracy and parallelism. Then, a cloud-edge collaborative framework leveraging pipeline parallelism, namely CEC-PA, is developed to minimize the overhead resulting from distributed task execution and context exchange by strategically partitioning and offloading model components across cloud and edge. Additionally, an election consensus mechanism is implemented within CEC-PA to ensure system robustness during coordinator node downtime. Comparative experiments and ablation studies are conducted to validate the effectiveness of the proposed distributed fault diagnosis approach. Our ensemble-based fault diagnosis model achieves a remarkable 97.4% accuracy on a real-world dataset collected by Nanjing Metro in Jiangsu Province, China. Meanwhile, CEC-PA demonstrates superior recovery proficiency during node disruptions and speed-up ranging from 1.98x to 7.93x in total inference time compared to its counterparts.