National radio dynamic zone (NRDZs) are intended to be geographically bounded areas within which controlled experiments can be carried out while protecting the nearby licensed users of the spectrum. An NRDZ will facilitate research and development of new spectrum technologies, waveforms, and protocols, in typical outdoor operational environments of such technologies. In this paper, we introduce and describe an NRDZ concept that relies on a combination of autonomous aerial and ground sensor nodes for spectrum sensing and radio environment monitoring (REM). We elaborate on key characteristics and features of an NRDZ to enable advanced wireless experimentation while also coexisting with licensed users. Some preliminary results based on simulation and experimental evaluations are also provided on out-of-zone leakage monitoring and real-time REMs.