Despite significant advancements in AI driven by neural networks, tree-based machine learning (TBML) models excel on tabular data. These models exhibit promising energy efficiency, and high performance, particularly when accelerated on analog content-addressable memory (aCAM) arrays. However, optimizing their hardware deployment, especially in leveraging TBML model structure and aCAM circuitry, remains challenging. In this paper, we introduce MonoSparse-CAM, a novel content-addressable memory (CAM) based computing optimization technique. MonoSparse-CAM efficiently leverages TBML model sparsity and CAM array circuits, enhancing processing performance. Our experiments show that MonoSparse-CAM reduces energy consumption by up to 28.56x compared to raw processing and 18.51x compared to existing deployment optimization techniques. Additionally, it consistently achieves at least 1.68x computational efficiency over current methods. By enabling energy-efficient CAM-based computing while preserving performance regardless of the array sparsity, MonoSparse-CAM addresses the high energy consumption problem of CAM which hinders processing of large arrays. Our contributions are twofold: we propose MonoSparse-CAM as an effective deployment optimization solution for CAM-based computing, and we investigate the impact of TBML model structure on array sparsity. This work provides crucial insights for energy-efficient TBML on hardware, highlighting a significant advancement in sustainable AI technologies.