Dexterous prosthetic hands have better grasp performance than traditional ones. However, patients still find it difficult to use these hands without a suitable control system. A new hybrid myoelectric control system, termed i-MYO, is presented and evaluated to solve this problem. The core component of the i-MYO is a novel grasp-type switching interface based on eye-tracking and augmented reality (AR), termed i-GSI. With the i-GSI, the user can easily switch a grasp type (six total) for a prosthetic hand by gazing at a GazeButton. The i-GSI is implemented in an AR helmet and is integrated, as an individual module, into the i-MYO system. In the i-MYO system, the myoelectric signal was used to control hand opening /closing proportionally. The operation of the i-MYO was tested on nine healthy subjects who wore HIT-V hand on the forearm and manipulated objects in a reach-and-grasp task. It was also tested on one patient who had an inferior myoelectric signal and was required to control the HIT-V hand to grasp objects. Results showed that in 91.6% of the trials, inexperienced healthy subjects accomplished the task within 5.9 s, and most failed trials were caused by a lack of experience in fine grasping. In addition, in about 1.5% of trials, the subjects also successfully transferred the objects but with a non-optimal grasp type. In 97.0% of the trials, the subjects spent ~1.3 s switching the optimal grasp types. A higher success rate in grasp type (99.1%) for the untrained patient has been observed thanks to more trials conducted. In 98.7 % of trials, the patient only needed another 2 s to control the hand to grasp the object after switching to the optimal grasp type. The tests demonstrate the control capability of the new system in multi-DOF prosthetics, and all inexperienced subjects were able to master the operation of the i-MYO quickly within a few pieces of training and apply it easily.