Advances in the state of the art for 3d human sensing are currently limited by the lack of visual datasets with 3d ground truth, including multiple people, in motion, operating in real-world environments, with complex illumination or occlusion, and potentially observed by a moving camera. Sophisticated scene understanding would require estimating human pose and shape as well as gestures, towards representations that ultimately combine useful metric and behavioral signals with free-viewpoint photo-realistic visualisation capabilities. To sustain progress, we build a large-scale photo-realistic dataset, Human-SPACE (HSPACE), of animated humans placed in complex synthetic indoor and outdoor environments. We combine a hundred diverse individuals of varying ages, gender, proportions, and ethnicity, with hundreds of motions and scenes, as well as parametric variations in body shape (for a total of 1,600 different humans), in order to generate an initial dataset of over 1 million frames. Human animations are obtained by fitting an expressive human body model, GHUM, to single scans of people, followed by novel re-targeting and positioning procedures that support the realistic animation of dressed humans, statistical variation of body proportions, and jointly consistent scene placement of multiple moving people. Assets are generated automatically, at scale, and are compatible with existing real time rendering and game engines. The dataset with evaluation server will be made available for research. Our large-scale analysis of the impact of synthetic data, in connection with real data and weak supervision, underlines the considerable potential for continuing quality improvements and limiting the sim-to-real gap, in this practical setting, in connection with increased model capacity.