Reinforcement Learning (RL) and Multi-Agent Reinforcement Learning (MARL) have emerged as promising methodologies for addressing challenges in automated cyber defence (ACD). These techniques offer adaptive decision-making capabilities in high-dimensional, adversarial environments. This report provides a structured set of guidelines for cybersecurity professionals and researchers to assess the suitability of RL and MARL for specific use cases, considering factors such as explainability, exploration needs, and the complexity of multi-agent coordination. It also discusses key algorithmic approaches, implementation challenges, and real-world constraints, such as data scarcity and adversarial interference. The report further outlines open research questions, including policy optimality, agent cooperation levels, and the integration of MARL systems into operational cybersecurity frameworks. By bridging theoretical advancements and practical deployment, these guidelines aim to enhance the effectiveness of AI-driven cyber defence strategies.