Deep neural networks (DNNs) are inherently vulnerable to well-designed input samples called adversarial examples. The adversary can easily fool DNNs by adding slight perturbations to the input. In this paper, we propose a novel black-box adversarial example attack named GreedyFool, which synthesizes adversarial examples based on the differential evolution and the greedy approximation. The differential evolution is utilized to evaluate the effects of perturbed pixels on the confidence of the DNNs-based classifier. The greedy approximation is an approximate optimization algorithm to automatically get adversarial perturbations. Existing works synthesize the adversarial examples by leveraging simple metrics to penalize the perturbations, which lack sufficient consideration of the human visual system (HVS), resulting in noticeable artifacts. In order to sufficient imperceptibility, we launch a lot of investigations into the HVS and design an integrated metric considering just noticeable distortion (JND), Weber-Fechner law, texture masking and channel modulation, which is proven to be a better metric to measure the perceptual distance between the benign examples and the adversarial ones. The experimental results demonstrate that the GreedyFool has several remarkable properties including black-box, 100% success rate, flexibility, automation and can synthesize the more imperceptible adversarial examples than the state-of-the-art pixel-wise methods.