Glioma Grade Predictions using Scattering Wavelet Transform-Based Radiomics

Glioma grading before the surgery is very critical for the prognosis prediction and treatment plan making. In this paper, we present a novel scattering wavelet-based radiomics method to predict noninvasively and accurately the glioma grades. The multimodal magnetic resonance images of 285 patients were used, with the intratumoral and peritumoral regions well labeled. The wavelet scattering-based features and traditional radiomics features were firstly extracted from both intratumoral and peritumoral regions respectively. The support vector machine (SVM), logistic regression (LR) and random forest (RF) were then trained with 5-fold cross validation to predict the glioma grades. The prediction obtained with different features was finally evaluated in terms of quantitative metrics. The area under the receiver operating characteristic curve (AUC) of glioma grade prediction based on scattering wavelet features was up to 0.99 when considering both intratumoral and peritumoral features in multimodal images, which increases by about 17% compared to traditional radiomics. Such results shown that the local invariant features extracted from the scattering wavelet transform allows improving the prediction accuracy for glioma grading. In addition, the features extracted from peritumoral regions further increases the accuracy of glioma grading.