Exploring Gaze Pattern in Autistic Children: Clustering, Visualization, and Prediction

Autism Spectrum Disorder (ASD) significantly affects the social and communication abilities of children, and eye-tracking is commonly used as a diagnostic tool by identifying associated atypical gaze patterns. Traditional methods demand manual identification of Areas of Interest in gaze patterns, lowering the performance of gaze behavior analysis in ASD subjects. To tackle this limitation, we propose a novel method to automatically analyze gaze behaviors in ASD children with superior accuracy. To be specific, we first apply and optimize seven clustering algorithms to automatically group gaze points to compare ASD subjects with typically developing peers. Subsequently, we extract 63 significant features to fully describe the patterns. These features can describe correlations between ASD diagnosis and gaze patterns. Lastly, using these features as prior knowledge, we train multiple predictive machine learning models to predict and diagnose ASD based on their gaze behaviors. To evaluate our method, we apply our method to three ASD datasets. The experimental and visualization results demonstrate the improvements of clustering algorithms in the analysis of unique gaze patterns in ASD children. Additionally, these predictive machine learning models achieved state-of-the-art prediction performance ($81\%$ AUC) in the field of automatically constructed gaze point features for ASD diagnosis. Our code is available at \url{https://github.com/username/projectname}.