Virtual assistants have been widely used by mobile phone users in recent years. Although their capabilities of processing user intents have been developed rapidly, virtual assistants in most platforms are only capable of handling pre-defined high-level tasks supported by extra manual efforts of developers. However, instance-level user intents containing more detailed objectives with complex practical situations, are yet rarely studied so far. In this paper, we explore virtual assistants capable of processing instance-level user intents based on pixels of application screens, without the requirements of extra extensions on the application side. We propose a novel cross-modal deep learning pipeline, which understands the input vocal or textual instance-level user intents, predicts the targeting operational area, and detects the absolute button area on screens without any metadata of applications. We conducted a user study with 10 participants to collect a testing dataset with instance-level user intents. The testing dataset is then utilized to evaluate the performance of our model, which demonstrates that our model is promising with the achievement of 64.43% accuracy on our testing dataset.