Distributed learning frameworks, which partition neural network models across multiple computing nodes, enhance efficiency in collaborative edge-cloud systems but may also introduce new vulnerabilities. In this work, we explore the feasibility of generating universal adversarial attacks when an attacker has access to the edge part of the model only, which consists in the first network layers. Unlike traditional universal adversarial perturbations (UAPs) that require full model knowledge, our approach shows that adversaries can induce effective mispredictions in the unknown cloud part by leveraging key features on the edge side. Specifically, we train lightweight classifiers from intermediate features available at the edge, i.e., before the split point, and use them in a novel targeted optimization to craft effective UAPs. Our results on ImageNet demonstrate strong attack transferability to the unknown cloud part. Additionally, we analyze the capability of an attacker to achieve targeted adversarial effect with edge-only knowledge, revealing intriguing behaviors. By introducing the first adversarial attacks with edge-only knowledge in split inference, this work underscores the importance of addressing partial model access in adversarial robustness, encouraging further research in this area.