Deep neural networks (DNNs)-powered Electrocardiogram (ECG) diagnosis systems emerge recently, and are expected to take over tedious examinations by cardiologists. However, their vulnerability to adversarial attacks still lack of comprehensive investigation. ECG recordings differ from images in the visualization, dynamic property and accessibility, thus, the existing image-targeted attack may not directly applicable. To fill this gap, this paper proposes ECGadv to explore the feasibility of adversarial attacks on arrhythmia classification system. We identify the main issues under two different deployment models(i.e., cloud-based and local-based) and propose effective attack schemes respectively. Our results demonstrate the blind spots of DNN-powered diagnosis system under adversarial attacks, which facilitates future researches on countermeasures.