Dissolving Is Amplifying: Towards Fine-Grained Anomaly Detection

Medical anomalous data normally contains fine-grained instance-wise additive feature patterns (e.g. tumor, hemorrhage), that are oftenly critical but insignificant. Interestingly, apart from the remarkable image generation abilities of diffusion models, we observed that diffusion models can dissolve image details for a given image, resulting in generalized feature representations. We hereby propose DIA, dissolving is amplifying, that amplifies fine-grained image features by contrasting an image against its feature dissolved counterpart. In particular, we show that diffusion models can serve as semantic preserving feature dissolvers that help learning fine-grained anomalous patterns for anomaly detection tasks, especially for medical domains with fine-grained feature differences. As a result, our method yields a novel fine-grained anomaly detection method, aims at amplifying instance-level feature patterns, that significantly improves medical anomaly detection accuracy in a large margin without any prior knowledge of explicit fine-grained anomalous feature patterns.