Multi-scale maps are essential representations of surveying and cartographic results, serving as fundamental components of geographic services. Current image generation networks can quickly produce map tiles from remote-sensing images. However, generative models designed for natural images often focus on texture features, neglecting the unique characteristics of remote-sensing features and the scale attributes of tile maps. This limitation in generative models impairs the accurate representation of geographic information, and the quality of tile map generation still needs improvement. Diffusion models have demonstrated remarkable success in various image generation tasks, highlighting their potential to address this challenge. This paper presents C2GM, a novel framework for generating multi-scale tile maps through conditional guided diffusion and multi-scale cascade generation. Specifically, we implement a conditional feature fusion encoder to extract object priors from remote sensing images and cascade reference double branch input, ensuring an accurate representation of complex features. Low-level generated tiles act as constraints for high-level map generation, enhancing visual continuity. Moreover, we incorporate map scale modality information using CLIP to simulate the relationship between map scale and cartographic generalization in tile maps. Extensive experimental evaluations demonstrate that C2GM consistently achieves the state-of-the-art (SOTA) performance on all metrics, facilitating the rapid and effective generation of multi-scale large-format maps for emergency response and remote mapping applications.