Brain tumor segmentation with missing modalities via latent multi-source correlation representation

Multimodal MR images can provide complementary information for accurate brain tumor segmentation. However, it's common to have missing imaging modalities in clinical practice. Since it exists a strong correlation between multi modalities, a novel correlation representation block is proposed to specially discover the latent multi-source correlation. Thanks to the obtained correlation representation, the segmentation becomes more robust in the case of missing modality. The model parameter estimation module first maps the individual representation produced by each encoder to obtain independent parameters, then, under these parameters, correlation expression module transforms all the individual representations to form a latent multi-source correlation representation. Finally, the correlation representations across modalities are fused via attention mechanism into a shared representation to emphasize the most important features for segmentation. We evaluate our model on BraTS 2018 datasets, it outperforms the current state-of-the-art method and produces robust results when one or more modalities are missing.