Due to the lack of labels and the domain diversities, it is a challenge to study person re-identification in the cross-domain setting. An admirable method is to optimize the target model by assigning pseudo-labels for unlabeled samples through clustering. Usually, attributed to the domain gaps, the pre-trained source domain model cannot extract appropriate target domain features, which will dramatically affect the clustering performance and the accuracy of pseudo-labels. Extensive label noise will lead to sub-optimal solutions doubtlessly. To solve these problems, we propose an Anti-Noise Learning (ANL) approach, which contains two modules. The Feature Distribution Alignment (FDA) module is designed to gather the id-related samples and disperse id-unrelated samples, through the camera-wise contrastive learning and adversarial adaptation. Creating a friendly cross-feature foundation for clustering that is to reduce clustering noise. Besides, the Reliable Sample Selection (RSS) module utilizes an Auxiliary Model to correct noisy labels and select reliable samples for the Main Model. In order to effectively utilize the outlier information generated by the clustering algorithm and RSS module, we train these samples at the instance-level. The experiments demonstrate that our proposed ANL framework can effectively reduce the domain conflicts and alleviate the influence of noisy samples, as well as superior performance compared with the state-of-the-art methods.