Active Learning Guided Federated Online Adaptation: Applications in Medical Image Segmentation

Data privacy, storage, and distribution shifts are major bottlenecks in medical image analysis. Data cannot be shared across patients, physicians, and facilities due to privacy concerns, usually requiring each patient's data to be analyzed in a discreet setting at a near real-time pace. However, one would like to take advantage of the accumulated knowledge across healthcare facilities as the computational systems analyze data of more and more patients while incorporating feedback provided by physicians to improve accuracy. Motivated by these, we propose a method for medical image segmentation that adapts to each incoming data batch (online adaptation), incorporates physician feedback through active learning, and assimilates knowledge across facilities in a federated setup. Combining an online adaptation scheme at test time with an efficient sampling strategy with budgeted annotation helps bridge the gap between the source and the incoming stream of target domain data. A federated setup allows collaborative aggregation of knowledge across distinct distributed models without needing to share the data across different models. This facilitates the improvement of performance over time by accumulating knowledge across users. Towards achieving these goals, we propose a computationally amicable, privacy-preserving image segmentation technique \textbf{DrFRODA} that uses federated learning to adapt the model in an online manner with feedback from doctors in the loop. Our experiments on publicly available datasets show that the proposed distributed active learning-based online adaptation method outperforms unsupervised online adaptation methods and shows competitive results with offline active learning-based adaptation methods.