General Intelligent Imaging and Uncertainty Quantification by Deterministic Diffusion Model

Computational imaging is crucial in many disciplines from autonomous driving to life sciences. However, traditional model-driven and iterative methods consume large computational power and lack scalability for imaging. Deep learning (DL) is effective in processing local-to-local patterns, but it struggles with handling universal global-to-local (nonlocal) patterns under current frameworks. To bridge this gap, we propose a novel DL framework that employs a progressive denoising strategy, named the deterministic diffusion model (DDM), to facilitate general computational imaging at a low cost. We experimentally demonstrate the efficient and faithful image reconstruction capabilities of DDM from nonlocal patterns, such as speckles from multimode fiber and intensity patterns of second harmonic generation, surpassing the capability of previous state-of-the-art DL algorithms. By embedding Bayesian inference into DDM, we establish a theoretical framework and provide experimental proof of its uncertainty quantification. This advancement ensures the predictive reliability of DDM, avoiding misjudgment in high-stakes scenarios. This versatile and integrable DDM framework can readily extend and improve the efficacy of existing DL-based imaging applications.

Recognizing three-dimensional phase images with deep learning

Optical phase contains key information for biomedical and astronomical imaging. However, it is often obscured by layers of heterogeneous and scattering media, which render optical phase imaging at different depths an utmost challenge. Limited by the memory effect, current methods for phase imaging in strong scattering media are inapplicable to retrieving phases at different depths. To address this challenge, we developed a speckle three-dimensional reconstruction network (STRN) to recognize phase objects behind scattering media, which circumvents the limitations of memory effect. From the single-shot, reference-free and scanning-free speckle pattern input, STRN distinguishes depth-resolving quantitative phase information with high fidelity. Our results promise broad applications in biomedical tomography and endoscopy.