Abstract:Natural Medicinal Materials (NMMs) have a long history of global clinical applications, accompanied by extensive informational records. Despite their significant impact on healthcare, the field faces a major challenge: the non-standardization of NMM knowledge, stemming from historical complexities and causing limitations in broader applications. To address this, we introduce a Systematic Nomenclature for NMMs, underpinned by ShennongAlpha, an AI-driven platform designed for intelligent knowledge acquisition. This nomenclature system enables precise identification and differentiation of NMMs. ShennongAlpha, cataloging over ten thousand NMMs with standardized bilingual information, enhances knowledge management and application capabilities, thereby overcoming traditional barriers. Furthermore, it pioneers AI-empowered conversational knowledge acquisition and standardized machine translation. These synergistic innovations mark the first major advance in integrating domain-specific NMM knowledge with AI, propelling research and applications across both NMM and AI fields while establishing a groundbreaking precedent in this crucial area.