Leveraging Large Language Models for Patient Engagement: The Power of Conversational AI in Digital Health

The rapid advancements in large language models (LLMs) have opened up new opportunities for transforming patient engagement in healthcare through conversational AI. This paper presents an overview of the current landscape of LLMs in healthcare, specifically focusing on their applications in analyzing and generating conversations for improved patient engagement. We showcase the power of LLMs in handling unstructured conversational data through four case studies: (1) analyzing mental health discussions on Reddit, (2) developing a personalized chatbot for cognitive engagement in seniors, (3) summarizing medical conversation datasets, and (4) designing an AI-powered patient engagement system. These case studies demonstrate how LLMs can effectively extract insights and summarizations from unstructured dialogues and engage patients in guided, goal-oriented conversations. Leveraging LLMs for conversational analysis and generation opens new doors for many patient-centered outcomes research opportunities. However, integrating LLMs into healthcare raises important ethical considerations regarding data privacy, bias, transparency, and regulatory compliance. We discuss best practices and guidelines for the responsible development and deployment of LLMs in healthcare settings. Realizing the full potential of LLMs in digital health will require close collaboration between the AI and healthcare professionals communities to address technical challenges and ensure these powerful tools' safety, efficacy, and equity.

Representation Learning for Person or Entity-centric Knowledge Graphs: An Application in Healthcare

Knowledge graphs (KGs) are a popular way to organise information based on ontologies or schemas and have been used across a variety of scenarios from search to recommendation. Despite advances in KGs, representing knowledge remains a non-trivial task across industries and it is especially challenging in the biomedical and healthcare domains due to complex interdependent relations between entities, heterogeneity, lack of standardization, and sparseness of data. KGs are used to discover diagnoses or prioritize genes relevant to disease, but they often rely on schemas that are not centred around a node or entity of interest, such as a person. Entity-centric KGs are relatively unexplored but hold promise in representing important facets connected to a central node and unlocking downstream tasks beyond graph traversal and reasoning, such as generating graph embeddings and training graph neural networks for a wide range of predictive tasks. This paper presents an end-to-end representation learning framework to extract entity-centric KGs from structured and unstructured data. We introduce a star-shaped ontology to represent the multiple facets of a person and use it to guide KG creation. Compact representations of the graphs are created leveraging graph neural networks and experiments are conducted using different levels of heterogeneity or explicitness. A readmission prediction task is used to evaluate the results of the proposed framework, showing a stable system, robust to missing data, that outperforms a range of baseline machine learning classifiers. We highlight that this approach has several potential applications across domains and is open-sourced. Lastly, we discuss lessons learned, challenges, and next steps for the adoption of the framework in practice.