Retuve: Automated Multi-Modality Analysis of Hip Dysplasia with Open Source AI

Developmental dysplasia of the hip (DDH) poses significant diagnostic challenges, hindering timely intervention. Current screening methodologies lack standardization, and AI-driven studies suffer from reproducibility issues due to limited data and code availability. To address these limitations, we introduce Retuve, an open-source framework for multi-modality DDH analysis, encompassing both ultrasound (US) and X-ray imaging. Retuve provides a complete and reproducible workflow, offering open datasets comprising expert-annotated US and X-ray images, pre-trained models with training code and weights, and a user-friendly Python Application Programming Interface (API). The framework integrates segmentation and landmark detection models, enabling automated measurement of key diagnostic parameters such as the alpha angle and acetabular index. By adhering to open-source principles, Retuve promotes transparency, collaboration, and accessibility in DDH research. This initiative has the potential to democratize DDH screening, facilitate early diagnosis, and ultimately improve patient outcomes by enabling widespread screening and early intervention. The GitHub repository/code can be found here: https://github.com/radoss-org/retuve

Weakly Supervised Medical Image Segmentation With Soft Labels and Noise Robust Loss

Recent advances in deep learning algorithms have led to significant benefits for solving many medical image analysis problems. Training deep learning models commonly requires large datasets with expert-labeled annotations. However, acquiring expert-labeled annotation is not only expensive but also is subjective, error-prone, and inter-/intra- observer variability introduces noise to labels. This is particularly a problem when using deep learning models for segmenting medical images due to the ambiguous anatomical boundaries. Image-based medical diagnosis tools using deep learning models trained with incorrect segmentation labels can lead to false diagnoses and treatment suggestions. Multi-rater annotations might be better suited to train deep learning models with small training sets compared to single-rater annotations. The aim of this paper was to develop and evaluate a method to generate probabilistic labels based on multi-rater annotations and anatomical knowledge of the lesion features in MRI and a method to train segmentation models using probabilistic labels using normalized active-passive loss as a "noise-tolerant loss" function. The model was evaluated by comparing it to binary ground truth for 17 knees MRI scans for clinical segmentation and detection of bone marrow lesions (BML). The proposed method successfully improved precision 14, recall 22, and Dice score 8 percent compared to a binary cross-entropy loss function. Overall, the results of this work suggest that the proposed normalized active-passive loss using soft labels successfully mitigated the effects of noisy labels.