Selective Inference for Time-Varying Effect Moderation

Causal effect moderation investigates how the effect of interventions (or treatments) on outcome variables changes based on observed characteristics of individuals, known as potential effect moderators. With advances in data collection, datasets containing many observed features as potential moderators have become increasingly common. High-dimensional analyses often lack interpretability, with important moderators masked by noise, while low-dimensional, marginal analyses yield many false positives due to strong correlations with true moderators. In this paper, we propose a two-step method for selective inference on time-varying causal effect moderation that addresses the limitations of both high-dimensional and marginal analyses. Our method first selects a relatively smaller, more interpretable model to estimate a linear causal effect moderation using a Gaussian randomization approach. We then condition on the selection event to construct a pivot, enabling uniformly asymptotic semi-parametric inference in the selected model. Through simulations and real data analyses, we show that our method consistently achieves valid coverage rates, even when existing conditional methods and common sample splitting techniques fail. Moreover, our method yields shorter, bounded intervals, unlike existing methods that may produce infinitely long intervals.

Bayes classifier cannot be learned from noisy responses with unknown noise rates

Training a classifier with noisy labels typically requires the learner to specify the distribution of label noise, which is often unknown in practice. Although there have been some recent attempts to relax that requirement, we show that the Bayes decision rule is unidentified in most classification problems with noisy labels. This suggests it is generally not possible to bypass/relax the requirement. In the special cases in which the Bayes decision rule is identified, we develop a simple algorithm to learn the Bayes decision rule, that does not require knowledge of the noise distribution.