Enhanced Cascade Prostate Cancer Classifier in mp-MRI Utilizing Recall Feedback Adaptive Loss and Prior Knowledge-Based Feature Extraction

Prostate cancer is the second most common cancer in males worldwide, and mpMRI is commonly used for diagnosis. However, interpreting mpMRI is challenging and requires expertise from radiologists. This highlights the urgent need for automated grading in mpMRI. Existing studies lack integration of clinical prior information and suffer from uneven training sample distribution due to prevalence. Therefore, we propose a solution that incorporates prior knowledge, addresses the issue of uneven medical sample distribution, and maintains high interpretability in mpMRI. Firstly, we introduce Prior Knowledge-Based Feature Extraction, which mathematically models the PI-RADS criteria for prostate cancer as diagnostic information into model training. Secondly, we propose Adaptive Recall Feedback Loss to address the extremely imbalanced data problem. This method adjusts the training dynamically based on accuracy and recall in the validation set, resulting in high accuracy and recall simultaneously in the testing set.Thirdly, we design an Enhanced Cascade Prostate Cancer Classifier that classifies prostate cancer into different levels in an interpretable way, which refines the classification results and helps with clinical intervention. Our method is validated through experiments on the PI-CAI dataset and outperforms other methods with a more balanced result in both accuracy and recall rate.