Abstract:In this paper, we delve into the rapidly evolving challenge of misinformation detection, with a specific focus on the nuanced manipulation of narrative frames - an under-explored area within the AI community. The potential for Generative AI models to generate misleading narratives underscores the urgency of this problem. Drawing from communication and framing theories, we posit that the presentation or 'framing' of accurate information can dramatically alter its interpretation, potentially leading to misinformation. We highlight this issue through real-world examples, demonstrating how shifts in narrative frames can transmute fact-based information into misinformation. To tackle this challenge, we propose an innovative approach leveraging the power of pre-trained Large Language Models and deep neural networks to detect misinformation originating from accurate facts portrayed under different frames. These advanced AI techniques offer unprecedented capabilities in identifying complex patterns within unstructured data critical for examining the subtleties of narrative frames. The objective of this paper is to bridge a significant research gap in the AI domain, providing valuable insights and methodologies for tackling framing-induced misinformation, thus contributing to the advancement of responsible and trustworthy AI technologies. Several experiments are intensively conducted and experimental results explicitly demonstrate the various impact of elements of framing theory proving the rationale of applying framing theory to increase the performance in misinformation detection.