Machine Learning-Based Differential Diagnosis of Parkinson's Disease Using Kinematic Feature Extraction and Selection

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair daily functioning. The severity of these symptoms is typically assessed using the MDS-UPDRS rating scale, which is subjective and dependent on the physician's experience. Additionally, PD shares symptoms with other neurodegenerative diseases, such as progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), complicating accurate diagnosis. To address these diagnostic challenges, we propose a machine learning-based system for differential diagnosis of PD, PSP, MSA, and healthy controls (HC). This system utilizes a kinematic feature-based hierarchical feature extraction and selection approach. Initially, 18 kinematic features are extracted, including two newly proposed features: Thumb-to-index vector velocity and acceleration, which provide insights into motor control patterns. In addition, 41 statistical features were extracted here from each kinematic feature, including some new approaches such as Average Absolute Change, Rhythm, Amplitude, Frequency, Standard Deviation of Frequency, and Slope. Feature selection is performed using One-way ANOVA to rank features, followed by Sequential Forward Floating Selection (SFFS) to identify the most relevant ones, aiming to reduce the computational complexity. The final feature set is used for classification, achieving a classification accuracy of 66.67% for each dataset and 88.89% for each patient, with particularly high performance for the MSA and HC groups using the SVM algorithm. This system shows potential as a rapid and accurate diagnostic tool in clinical practice, though further data collection and refinement are needed to enhance its reliability.

EMG-Based Hand Gesture Recognition through Diverse Domain Feature Enhancement and Machine Learning-Based Approach

Surface electromyography (EMG) serves as a pivotal tool in hand gesture recognition and human-computer interaction, offering a non-invasive means of signal acquisition. This study presents a novel methodology for classifying hand gestures using EMG signals. To address the challenges associated with feature extraction where, we explored 23 distinct morphological, time domain and frequency domain feature extraction techniques. However, the substantial size of the features may increase the computational complexity issues that can hinder machine learning algorithm performance. We employ an efficient feature selection approach, specifically an extra tree classifier, to mitigate this. The selected potential feature fed into the various machine learning-based classification algorithms where our model achieved 97.43\% accuracy with the KNN algorithm and selected feature. By leveraging a comprehensive feature extraction and selection strategy, our methodology enhances the accuracy and usability of EMG-based hand gesture recognition systems. The higher performance accuracy proves the effectiveness of the proposed model over the existing system. \keywords{EMG signal, machine learning approach, hand gesture recognition.