ADAM-1: AI and Bioinformatics for Alzheimer's Detection and Microbiome-Clinical Data Integrations

The Alzheimer's Disease Analysis Model Generation 1 (ADAM) is a multi-agent large language model (LLM) framework designed to integrate and analyze multi-modal data, including microbiome profiles, clinical datasets, and external knowledge bases, to enhance the understanding and detection of Alzheimer's disease (AD). By leveraging retrieval-augmented generation (RAG) techniques along with its multi-agent architecture, ADAM-1 synthesizes insights from diverse data sources and contextualizes findings using literature-driven evidence. Comparative evaluation against XGBoost revealed similar mean F1 scores but significantly reduced variance for ADAM-1, highlighting its robustness and consistency, particularly in small laboratory datasets. While currently tailored for binary classification tasks, future iterations aim to incorporate additional data modalities, such as neuroimaging and biomarkers, to broaden the scalability and applicability for Alzheimer's research and diagnostics.

Planarian Neural Networks: Evolutionary Patterns from Basic Bilateria Shaping Modern Artificial Neural Network Architectures

This study examined the viability of enhancing the prediction accuracy of artificial neural networks (ANNs) in image classification tasks by developing ANNs with evolution patterns similar to those of biological neural networks. ResNet is a widely used family of neural networks with both deep and wide variants; therefore, it was selected as the base model for our investigation. The aim of this study is to improve the image classification performance of ANNs via a novel approach inspired by the biological nervous system architecture of planarians, which comprises a brain and two nerve cords. We believe that the unique neural architecture of planarians offers valuable insights into the performance enhancement of ANNs. The proposed planarian neural architecture-based neural network was evaluated on the CIFAR-10 and CIFAR-100 datasets. Our results indicate that the proposed method exhibits higher prediction accuracy than the baseline neural network models in image classification tasks. These findings demonstrate the significant potential of biologically inspired neural network architectures in improving the performance of ANNs in a wide range of applications.

Computational music analysis from first principles

We use coupled hidden Markov models to automatically annotate the 371 Bach chorales in the Riemenschneider edition, a corpus containing approximately 100,000 notes and 20,000 chords. We give three separate analyses that achieve progressively greater accuracy at the cost of making increasingly strong assumptions about musical syntax. Although our method makes almost no use of human input, we are able to identify both chords and keys with an accuracy of 85% or greater when compared to an expert human analysis, resulting in annotations accurate enough to be used for a range of music-theoretical purposes, while also being free of subjective human judgments. Our work bears on longstanding debates about the objective reality of the structures postulated by standard Western harmonic theory, as well as on specific questions about the nature of Western harmonic syntax.