A One-Shot Learning Framework for Assessment of Fibrillar Collagen from Second Harmonic Generation Images of an Infarcted Myocardium

Myocardial infarction (MI) is a scientific term that refers to heart attack. In this study, we infer highly relevant second harmonic generation (SHG) cues from collagen fibers exhibiting highly non-centrosymmetric assembly together with two-photon excited cellular autofluorescence in infarcted mouse heart to quantitatively probe fibrosis, especially targeted at an early stage after MI. We present a robust one-shot machine learning algorithm that enables determination of 2D assembly of collagen with high spatial resolution along with its structural arrangement in heart tissues post-MI with spectral specificity and sensitivity. Detection, evaluation, and precise quantification of fibrosis extent at early stage would guide one to develop treatment therapies that may prevent further progression and determine heart transplant needs for patient survival.

Deep Adaptive Wavelet Network

Even though convolutional neural networks have become the method of choice in many fields of computer vision, they still lack interpretability and are usually designed manually in a cumbersome trial-and-error process. This paper aims at overcoming those limitations by proposing a deep neural network, which is designed in a systematic fashion and is interpretable, by integrating multiresolution analysis at the core of the deep neural network design. By using the lifting scheme, it is possible to generate a wavelet representation and design a network capable of learning wavelet coefficients in an end-to-end form. Compared to state-of-the-art architectures, the proposed model requires less hyper-parameter tuning and achieves competitive accuracy in image classification tasks