Abstract:Small Angle Neutron Scattering (SANS) is a non-destructive technique utilized to probe the nano- to mesoscale structure of materials by analyzing the scattering pattern of neutrons. Accelerating SANS acquisition for in-situ analysis is essential, but it often reduces the signal-to-noise ratio (SNR), highlighting the need for methods to enhance SNR even with short acquisition times. While deep learning (DL) can be used for enhancing SNR of low quality SANS, the amount of experimental data available for training is usually severely limited. We address this issue by proposing a Plug-and-play Restoration for SANS (PR-SANS) that uses domain-adapted priors. The prior in PR-SANS is initially trained on a set of generic images and subsequently fine-tuned using a limited amount of experimental SANS data. We present a theoretical convergence analysis of PR-SANS by focusing on the error resulting from using inexact domain-adapted priors instead of the ideal ones. We demonstrate with experimentally collected SANS data that PR-SANS can recover high-SNR 2D SANS detector images from low-SNR detector images, effectively increasing the SNR. This advancement enables a reduction in acquisition times by a factor of 12 while maintaining the original signal quality.