Optimizing Ingredient Substitution Using Large Language Models to Enhance Phytochemical Content in Recipes

In the emerging field of computational gastronomy, aligning culinary practices with scientifically supported nutritional goals is increasingly important. This study explores how large language models (LLMs) can be applied to optimize ingredient substitutions in recipes, specifically to enhance the phytochemical content of meals. Phytochemicals are bioactive compounds found in plants, which, based on preclinical studies, may offer potential health benefits. We fine-tuned models, including OpenAI's GPT-3.5, DaVinci, and Meta's TinyLlama, using an ingredient substitution dataset. These models were used to predict substitutions that enhance phytochemical content and create a corresponding enriched recipe dataset. Our approach improved Hit@1 accuracy on ingredient substitution tasks, from the baseline 34.53 plus-minus 0.10% to 38.03 plus-minus 0.28% on the original GISMo dataset, and from 40.24 plus-minus 0.36% to 54.46 plus-minus 0.29% on a refined version of the same dataset. These substitutions led to the creation of 1,951 phytochemically enriched ingredient pairings and 1,639 unique recipes. While this approach demonstrates potential in optimizing ingredient substitutions, caution must be taken when drawing conclusions about health benefits, as the claims are based on preclinical evidence. Future work should include clinical validation and broader datasets to further evaluate the nutritional impact of these substitutions. This research represents a step forward in using AI to promote healthier eating practices, providing potential pathways for integrating computational methods with nutritional science.

Foundational Models for Pathology and Endoscopy Images: Application for Gastric Inflammation

The integration of artificial intelligence (AI) in medical diagnostics represents a significant advancement in managing upper gastrointestinal (GI) cancer, a major cause of global cancer mortality. Specifically for gastric cancer (GC), chronic inflammation causes changes in the mucosa such as atrophy, intestinal metaplasia (IM), dysplasia and ultimately cancer. Early detection through endoscopic regular surveillance is essential for better outcomes. Foundation models (FM), which are machine or deep learning models trained on diverse data and applicable to broad use cases, offer a promising solution to enhance the accuracy of endoscopy and its subsequent pathology image analysis. This review explores the recent advancements, applications, and challenges associated with FM in endoscopy and pathology imaging. We started by elucidating the core principles and architectures underlying these models, including their training methodologies and the pivotal role of large-scale data in developing their predictive capabilities. Moreover, this work discusses emerging trends and future research directions, emphasizing the integration of multimodal data, the development of more robust and equitable models, and the potential for real-time diagnostic support. This review aims to provide a roadmap for researchers and practitioners in navigating the complexities of incorporating FM into clinical practice for prevention/management of GC cases, thereby improving patient outcomes.