Position Paper: Building Trust in Synthetic Data for Clinical AI

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown rapidly and demonstrated substantial theoretical potential, its practical adoption in clinical settings remains limited. Despite the benefits synthetic data offers, questions surrounding its reliability and credibility persist, leading to a lack of trust among clinicians. This position paper argues that fostering trust in synthetic medical data is crucial for its clinical adoption. It aims to spark a discussion on the viability of synthetic medical data in clinical practice, particularly in the context of current advancements in AI. We present empirical evidence from brain tumor segmentation to demonstrate that the quality, diversity, and proportion of synthetic data directly impact trust in clinical AI models. Our findings provide insights to improve the deployment and acceptance of synthetic data-driven AI systems in real-world clinical workflows.

Synthetic Simplicity: Unveiling Bias in Medical Data Augmentation

Synthetic data is becoming increasingly integral in data-scarce fields such as medical imaging, serving as a substitute for real data. However, its inherent statistical characteristics can significantly impact downstream tasks, potentially compromising deployment performance. In this study, we empirically investigate this issue and uncover a critical phenomenon: downstream neural networks often exploit spurious distinctions between real and synthetic data when there is a strong correlation between the data source and the task label. This exploitation manifests as \textit{simplicity bias}, where models overly rely on superficial features rather than genuine task-related complexities. Through principled experiments, we demonstrate that the source of data (real vs.\ synthetic) can introduce spurious correlating factors leading to poor performance during deployment when the correlation is absent. We first demonstrate this vulnerability on a digit classification task, where the model spuriously utilizes the source of data instead of the digit to provide an inference. We provide further evidence of this phenomenon in a medical imaging problem related to cardiac view classification in echocardiograms, particularly distinguishing between 2-chamber and 4-chamber views. Given the increasing role of utilizing synthetic datasets, we hope that our experiments serve as effective guidelines for the utilization of synthetic datasets in model training.