Abstract:Significance: We demonstrated the potential of using domain adaptation on functional Near-Infrared Spectroscopy (fNIRS) data to detect and discriminate different levels of n-back tasks that involve working memory across different experiment sessions and subjects. Aim: To address the domain shift in fNIRS data across sessions and subjects for task label alignment, we exploited two domain adaptation approaches - Gromov-Wasserstein (G-W) and Fused Gromov-Wasserstein (FG-W). Approach: We applied G-W for session-by-session alignment and FG-W for subject-by-subject alignment with Hellinger distance as underlying metric to fNIRS data acquired during different n-back task levels. We also compared with a supervised method - Convolutional Neural Network (CNN). Results: For session-by-session alignment, using G-W resulted in alignment accuracy of 70 $\pm$ 4 % (weighted mean $\pm$ standard error), whereas using CNN resulted in classification accuracy of 58 $\pm$ 5 % across five subjects. For subject-by-subject alignment, using FG-W resulted in alignment accuracy of 55 $\pm$ 3 %, whereas using CNN resulted in classification accuracy of 45 $\pm$ 1 %. Where in both cases 25 % represents chance. We also showed that removal of motion artifacts from the fNIRS data plays an important role in improving alignment performance. Conclusions: Domain adaptation is potential for session-by-session and subject-by-subject alignment using fNIRS data.