Synthetic dual image generation for reduction of labeling efforts in semantic segmentation of micrographs with a customized metric function

Training of semantic segmentation models for material analysis requires micrographs and their corresponding masks. It is quite unlikely that perfect masks will be drawn, especially at the edges of objects, and sometimes the amount of data that can be obtained is small, since only a few samples are available. These aspects make it very problematic to train a robust model. We demonstrate a workflow for the improvement of semantic segmentation models of micrographs through the generation of synthetic microstructural images in conjunction with masks. The workflow only requires joining a few micrographs with their respective masks to create the input for a Vector Quantised-Variational AutoEncoder model that includes an embedding space, which is trained such that a generative model (PixelCNN) learns the distribution of each input, transformed into discrete codes, and can be used to sample new codes. The latter will eventually be decoded by VQ-VAE to generate images alongside corresponding masks for semantic segmentation. To evaluate the synthetic data, we have trained U-Net models with different amounts of these synthetic data in conjunction with real data. These models were then evaluated using non-synthetic images only. Additionally, we introduce a customized metric derived from the mean Intersection over Union (mIoU). The proposed metric prevents a few falsely predicted pixels from greatly reducing the value of the mIoU. We have achieved a reduction in sample preparation and acquisition times, as well as the efforts, needed for image processing and labeling tasks, are less when it comes to training semantic segmentation model. The approach could be generalized to various types of image data such that it serves as a user-friendly solution for training models with a small number of real images.

FastCAR: Fast Classification And Regression Multi-Task Learning via Task Consolidation for Modelling a Continuous Property Variable of Object Classes

FastCAR is a novel task consolidation approach in Multi-Task Learning (MTL) for a classification and a regression task, despite task heterogeneity with only subtle correlation. It addresses object classification and continuous property variable regression, a crucial use case in science and engineering. FastCAR involves a labeling transformation approach that can be used with a single-task regression network architecture. FastCAR outperforms traditional MTL model families, parametrized in the landscape of architecture and loss weighting schemes, when learning of both tasks are collectively considered (classification accuracy of 99.54%, regression mean absolute percentage error of 2.3%). The experiments performed used an Advanced Steel Property dataset contributed by us. The dataset comprises 4536 images of 224x224 pixels, annotated with object classes and hardness properties that take continuous values. With the labeling transformation and single-task regression network architecture, FastCAR achieves reduced latency and time efficiency.

Spotlight on nerves: Portable multispectral optoacoustic imaging of peripheral nerve vascularization and morphology

Various morphological and functional parameters of peripheral nerves and their vascular supply are indicative of pathological changes due to injury or disease. Based on recent improvements in optoacoustic image quality, we explore the ability of multispectral optoacoustic tomography, in tandem with ultrasound imaging (OPUS), to investigate the vascular environment and morphology of peripheral nerves in vivo in a pilot study on healthy volunteers. We showcase the unique ability of optoacoustic imaging to visualize the vasa nervorum by observing intraneurial vessels in healthy nerves in vivo for the first time. In addition, we demonstrate that the label-free spectral optoacoustic contrast of the perfused connective tissue of peripheral nerves can be linked to the endogenous contrast of haemoglobin and collagen. We introduce metrics to analyze the composition of tissue based on its optoacoustic contrast and show that the high-resolution spectral contrast reveals specific differences between nervous tissue and reference tissue in the nerve's surrounding. We discuss how this showcased extraction of peripheral nerve characteristics using multispectral optoacoustic and ultrasound imaging can offer new insights into the pathophysiology of nerve damage and neuropathies, for example, in the context of diabetes.