iSight: Towards expert-AI co-assessment for improved immunohistochemistry staining interpretation

Immunohistochemistry (IHC) provides information on protein expression in tissue sections and is commonly used to support pathology diagnosis and disease triage. While AI models for H\&E-stained slides show promise, their applicability to IHC is limited due to domain-specific variations. Here we introduce HPA10M, a dataset that contains 10,495,672 IHC images from the Human Protein Atlas with comprehensive metadata included, and encompasses 45 normal tissue types and 20 major cancer types. Based on HPA10M, we trained iSight, a multi-task learning framework for automated IHC staining assessment. iSight combines visual features from whole-slide images with tissue metadata through a token-level attention mechanism, simultaneously predicting staining intensity, location, quantity, tissue type, and malignancy status. On held-out data, iSight achieved 85.5\% accuracy for location, 76.6\% for intensity, and 75.7\% for quantity, outperforming fine-tuned foundation models (PLIP, CONCH) by 2.5--10.2\%. In addition, iSight demonstrates well-calibrated predictions with expected calibration errors of 0.0150-0.0408. Furthermore, in a user study with eight pathologists evaluating 200 images from two datasets, iSight outperformed initial pathologist assessments on the held-out HPA dataset (79\% vs 68\% for location, 70\% vs 57\% for intensity, 68\% vs 52\% for quantity). Inter-pathologist agreement also improved after AI assistance in both held-out HPA (Cohen's $κ$ increased from 0.63 to 0.70) and Stanford TMAD datasets (from 0.74 to 0.76), suggesting expert--AI co-assessment can improve IHC interpretation. This work establishes a foundation for AI systems that can improve IHC diagnostic accuracy and highlights the potential for integrating iSight into clinical workflows to enhance the consistency and reliability of IHC assessment.

DeforHMR: Vision Transformer with Deformable Cross-Attention for 3D Human Mesh Recovery

Human Mesh Recovery (HMR) is an important yet challenging problem with applications across various domains including motion capture, augmented reality, and biomechanics. Accurately predicting human pose parameters from a single image remains a challenging 3D computer vision task. In this work, we introduce DeforHMR, a novel regression-based monocular HMR framework designed to enhance the prediction of human pose parameters using deformable attention transformers. DeforHMR leverages a novel query-agnostic deformable cross-attention mechanism within the transformer decoder to effectively regress the visual features extracted from a frozen pretrained vision transformer (ViT) encoder. The proposed deformable cross-attention mechanism allows the model to attend to relevant spatial features more flexibly and in a data-dependent manner. Equipped with a transformer decoder capable of spatially-nuanced attention, DeforHMR achieves state-of-the-art performance for single-frame regression-based methods on the widely used 3D HMR benchmarks 3DPW and RICH. By pushing the boundary on the field of 3D human mesh recovery through deformable attention, we introduce an new, effective paradigm for decoding local spatial information from large pretrained vision encoders in computer vision.