Bridging the Gap in Drug Safety Data Analysis: Large Language Models for SQL Query Generation

Pharmacovigilance (PV) is essential for drug safety, primarily focusing on adverse event monitoring. Traditionally, accessing safety data required database expertise, limiting broader use. This paper introduces a novel application of Large Language Models (LLMs) to democratize database access for non-technical users. Utilizing OpenAI's GPT-4, we developed a chatbot that generates structured query language (SQL) queries from natural language, bridging the gap between domain knowledge and technical requirements. The proposed application aims for more inclusive and efficient data access, enhancing decision making in drug safety. By providing LLMs with plain language summaries of expert knowledge, our approach significantly improves query accuracy over methods relying solely on database schemas. The application of LLMs in this context not only optimizes PV data analysis, ensuring timely and precise drug safety reporting -- a crucial component in adverse drug reaction monitoring -- but also promotes safer pharmacological practices and informed decision making across various data intensive fields.

Extending Consequence-Based Reasoning to SRIQ

Consequence-based calculi are a family of reasoning algorithms for description logics (DLs), and they combine hypertableau and resolution in a way that often achieves excellent performance in practice. Up to now, however, they were proposed for either Horn DLs (which do not support disjunction), or for DLs without counting quantifiers. In this paper we present a novel consequence-based calculus for SRIQ---a rich DL that supports both features. This extension is non-trivial since the intermediate consequences that need to be derived during reasoning cannot be captured using DLs themselves. The results of our preliminary performance evaluation suggest the feasibility of our approach in practice.