Multiparametric Deep Learning Tissue Signatures for Muscular Dystrophy: Preliminary Results

A current clinical challenge is identifying limb girdle muscular dystrophy 2I(LGMD2I)tissue changes in the thighs, in particular, separating fat, fat-infiltrated muscle, and muscle tissue. Deep learning algorithms have the ability to learn different features by using the inherent tissue contrasts from multiparametric magnetic resonance imaging (mpMRI). To that end, we developed a novel multiparametric deep learning network (MPDL) tissue signature model based on mpMRI and applied it to LGMD2I. We demonstrate a new tissue signature model of muscular dystrophy with the MPDL algorithm segments different tissue types with excellent results.

Multiparametric Deep Learning and Radiomics for Tumor Grading and Treatment Response Assessment of Brain Cancer: Preliminary Results

Radiomics is an exciting new area of texture research for extracting quantitative and morphological characteristics of pathological tissue. However, to date, only single images have been used for texture analysis. We have extended radiomic texture methods to use multiparametric (mp) data to get more complete information from all the images. These mpRadiomic methods could potentially provide a platform for stratification of tumor grade as well as assessment of treatment response in brain tumors. In brain, multiparametric MRI (mpMRI) are based on contrast enhanced T1-weighted imaging (T1WI), T2WI, Fluid Attenuated Inversion Recovery (FLAIR), Diffusion Weighted Imaging (DWI) and Perfusion Weighted Imaging (PWI). Therefore, we applied our multiparametric radiomic framework (mpRadiomic) on 24 patients with brain tumors (8 grade II and 16 grade IV). The mpRadiomic framework classified grade IV tumors from grade II tumors with a sensitivity and specificity of 93% and 100%, respectively, with an AUC of 0.95. For treatment response, the mpRadiomic framework classified pseudo-progression from true-progression with an AUC of 0.93. In conclusion, the mpRadiomic analysis was able to effectively capture the multiparametric brain MRI texture and could be used as potential biomarkers for distinguishing grade IV from grade II tumors as well as determining true-progression from pseudo-progression.