Leveraging Auxiliary Classification for Rib Fracture Segmentation

Thoracic trauma often results in rib fractures, which demand swift and accurate diagnosis for effective treatment. However, detecting these fractures on rib CT scans poses considerable challenges, involving the analysis of many image slices in sequence. Despite notable advancements in algorithms for automated fracture segmentation, the persisting challenges stem from the diverse shapes and sizes of these fractures. To address these issues, this study introduces a sophisticated deep-learning model with an auxiliary classification task designed to enhance the accuracy of rib fracture segmentation. The auxiliary classification task is crucial in distinguishing between fractured ribs and negative regions, encompassing non-fractured ribs and surrounding tissues, from the patches obtained from CT scans. By leveraging this auxiliary task, the model aims to improve feature representation at the bottleneck layer by highlighting the regions of interest. Experimental results on the RibFrac dataset demonstrate significant improvement in segmentation performance.

RibCageImp: A Deep Learning Framework for 3D Ribcage Implant Generation

The recovery of damaged or resected ribcage structures requires precise, custom-designed implants to restore the integrity and functionality of the thoracic cavity. Traditional implant design methods rely mainly on manual processes, making them time-consuming and susceptible to variability. In this work, we explore the feasibility of automated ribcage implant generation using deep learning. We present a framework based on 3D U-Net architecture that processes CT scans to generate patient-specific implant designs. To the best of our knowledge, this is the first investigation into automated thoracic implant generation using deep learning approaches. Our preliminary results, while moderate, highlight both the potential and the significant challenges in this complex domain. These findings establish a foundation for future research in automated ribcage reconstruction and identify key technical challenges that need to be addressed for practical implementation.

Enhanced Survival Prediction in Head and Neck Cancer Using Convolutional Block Attention and Multimodal Data Fusion

Accurate survival prediction in head and neck cancer (HNC) is essential for guiding clinical decision-making and optimizing treatment strategies. Traditional models, such as Cox proportional hazards, have been widely used but are limited in their ability to handle complex multi-modal data. This paper proposes a deep learning-based approach leveraging CT and PET imaging modalities to predict survival outcomes in HNC patients. Our method integrates feature extraction with a Convolutional Block Attention Module (CBAM) and a multi-modal data fusion layer that combines imaging data to generate a compact feature representation. The final prediction is achieved through a fully parametric discrete-time survival model, allowing for flexible hazard functions that overcome the limitations of traditional survival models. We evaluated our approach using the HECKTOR and HEAD-NECK-RADIOMICS- HN1 datasets, demonstrating its superior performance compared to conconventional statistical and machine learning models. The results indicate that our deep learning model significantly improves survival prediction accuracy, offering a robust tool for personalized treatment planning in HNC

Survival Prediction in Lung Cancer through Multi-Modal Representation Learning

Survival prediction is a crucial task associated with cancer diagnosis and treatment planning. This paper presents a novel approach to survival prediction by harnessing comprehensive information from CT and PET scans, along with associated Genomic data. Current methods rely on either a single modality or the integration of multiple modalities for prediction without adequately addressing associations across patients or modalities. We aim to develop a robust predictive model for survival outcomes by integrating multi-modal imaging data with genetic information while accounting for associations across patients and modalities. We learn representations for each modality via a self-supervised module and harness the semantic similarities across the patients to ensure the embeddings are aligned closely. However, optimizing solely for global relevance is inadequate, as many pairs sharing similar high-level semantics, such as tumor type, are inadvertently pushed apart in the embedding space. To address this issue, we use a cross-patient module (CPM) designed to harness inter-subject correspondences. The CPM module aims to bring together embeddings from patients with similar disease characteristics. Our experimental evaluation of the dataset of Non-Small Cell Lung Cancer (NSCLC) patients demonstrates the effectiveness of our approach in predicting survival outcomes, outperforming state-of-the-art methods.

Translating Imaging to Genomics: Leveraging Transformers for Predictive Modeling

In this study, we present a novel approach for predicting genomic information from medical imaging modalities using a transformer-based model. We aim to bridge the gap between imaging and genomics data by leveraging transformer networks, allowing for accurate genomic profile predictions from CT/MRI images. Presently most studies rely on the use of whole slide images (WSI) for the association, which are obtained via invasive methodologies. We propose using only available CT/MRI images to predict genomic sequences. Our transformer based approach is able to efficiently generate associations between multiple sequences based on CT/MRI images alone. This work paves the way for the use of non-invasive imaging modalities for precise and personalized healthcare, allowing for a better understanding of diseases and treatment.