Out-of-distribution (OoD) detection techniques are instrumental for safety-related neural networks. We are arguing, however, that current performance-oriented OoD detection techniques geared towards matching metrics such as expected calibration error, are not sufficient for establishing safety claims. What is missing is a rigorous design approach for developing, verifying, and validating OoD detectors. These design principles need to be aligned with the intended functionality and the operational domain. Here, we formulate some of the key technical challenges, together with a possible way forward, for developing a rigorous and safety-related design methodology for OoD detectors.