Existing DeepFake detection techniques primarily focus on facial manipulations, such as face-swapping or lip-syncing. However, advancements in text-to-video (T2V) and image-to-video (I2V) generative models now allow fully AI-generated synthetic content and seamless background alterations, challenging face-centric detection methods and demanding more versatile approaches. To address this, we introduce the \underline{U}niversal \underline{N}etwork for \underline{I}dentifying \underline{T}ampered and synth\underline{E}tic videos (\texttt{UNITE}) model, which, unlike traditional detectors, captures full-frame manipulations. \texttt{UNITE} extends detection capabilities to scenarios without faces, non-human subjects, and complex background modifications. It leverages a transformer-based architecture that processes domain-agnostic features extracted from videos via the SigLIP-So400M foundation model. Given limited datasets encompassing both facial/background alterations and T2V/I2V content, we integrate task-irrelevant data alongside standard DeepFake datasets in training. We further mitigate the model's tendency to over-focus on faces by incorporating an attention-diversity (AD) loss, which promotes diverse spatial attention across video frames. Combining AD loss with cross-entropy improves detection performance across varied contexts. Comparative evaluations demonstrate that \texttt{UNITE} outperforms state-of-the-art detectors on datasets (in cross-data settings) featuring face/background manipulations and fully synthetic T2V/I2V videos, showcasing its adaptability and generalizable detection capabilities.